As the story progresses, the sisters' lives become entangled with those of two brothers, Lorenzo and Carlos, who come from a wealthy and influential family. Alma falls in love with Lorenzo, while Graciela has a relationship with Carlos. However, their relationships are not without obstacles, as Mama Dolores disapproves of Alma and Lorenzo's relationship, while Carlos's mother is opposed to her son marrying someone from a lower social class.

The central theme of Cadenas de amargura is the struggle of the two sisters to overcome the societal barriers that prevent them from being happy. Alma fights against the rigid social norms that confine her, while Graciela struggles to break free from her submissive personality and find her own voice. Throughout the show, the sisters endure numerous challenges and betrayals, leading to a gripping and emotional storyline.