Genetics, usage of certain medications, hormone imbalance or excess weight, can cause some men to develop enlarged breasts. Even though weight loss will help with the issue of enlarged male breasts for some men, there are times when excess glandular tissue will cause even very lean patients to have the appearance of enlarged breasts. This results in a loss of confidence and self-assurance in many men as they become conscious of their appearance. They can get male breast reduction surgery to get rid of this issue.