Getting pregnant after 40 comes with unique challenges, but advances in regenerative medicine are giving women renewed hope where traditional treatments have fallen short. One of the most significant breakthroughs in late fertility care is Platelet-Rich Plasma therapy, which is now being used to address two of the most common obstacles women over 40 face — declining egg quality and thin endometrial lining.

A thin endometrium is one of the leading causes of failed embryo implantation and recurrent IVF failure. Research has shown that in women with thin endometrium, endometrial thickness increases and both chemical and clinical pregnancy rates improve following autologous PRP therapy. Studies have demonstrated that after PRP infusion, endometrial thickness increased significantly, with implantation rates and clinical pregnancy rates in the PRP group being notably higher compared to control groups. 

For women over 40, the results are equally encouraging. A recent study involving 510 women with poor ovarian response and an average age of 40.3 found that PRP treatments resulted in a pregnancy rate of 20.5% and a sustained live birth rate of 12.9%. 

Patients who may benefit from PRP fertility treatment include women with low AMH, diminished ovarian reserve, premature ovarian insufficiency, poor egg quality, thin endometrial lining, repeated IVF failure, or women over 40 exploring additional fertility options beyond standard protocols. 

Age is not the end of your fertility story — PRP therapy may be the turning point you have been waiting for.